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Edward J. Sachar, MD; Leon Hellman, MD; Jacob Kream, PhD; David K. Fukushima, PhD; Thomas F. Gallagher, PhD

Arch Gen Psychiatry. 1970;22(4):304-307.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

LITHIUM salts are now an increasingly used therapy for manic-depressive illness. They have been shown to be strikingly effective in the treatment of manic attacks and in the prophylaxis of recurrent manic episodes. Lithium salts may also have some prophylactic effect in diminishing the frequency of recurrent depressions.¹ Their mode of action remains obscure, however, although effects on several biological systems have been noted.² Platman and Fieve³ recently reported a frequent and substantial increase in the 8 AM levels of plasma cortisol in association with lithium ion therapy.³ While the serum levels of lithium ion in these patients were not reported, they were all in the therapeutic range (above 0.6 mEq/ liter).

To study further the possibility of a significant effect of lithium ion on adrenocortical activity, a group of patients were studied before and during lithium-carbonate therapy, utilizing isotopic measures of corti . . . [Full Text PDF of this Article]

Author Affiliations
Bronx, NY

From the Psychoendocrine Laboratories (Dr. Sachar), the Division of Neoplastic Medicine (Drs. Hellman and Kream), the Institute for Steroid Research (Drs. Fukushima and Gallagher), of the Montefiore Hospital and Medical Center and the Albert Einstein College of Medicine (Drs. Sachar, Hellman, Fukushima, and Gallagher), Bronx, NY.

Footnotes
Submitted for publication Sept 18, 1969.

Reprint requests to Department of Psychiatry, Montefiore Hospital and Medical Center, 111 E 210th St, Bronx, NY 10467 (Dr. Sachar).

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