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Study of Psychiatric Patients and Their Relatives

Herbert Y. Meltzer, MD; Ronald Moline, MD

Arch Gen Psychiatry. 1970;22(5):390-397.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

INCREASED plasma activity of the enzymes creatine kinase (CPK) or aldolase, or both, has been reported to occur in a large percentage of acutely psychotic patients of all diagnostic types.^1-7The increases in CPK activity are generally five to ten times the upper limits of normal, which, in our laboratory, are 50 international units (IU) per liter for hospitalized patients, 80 IU/ liter for fully active individuals^3,5; the in creased aldolase activity is usually two to three times the upper limits of normal. The increases usually occur in the first and second weeks of a psychotic episode, but may occur earlier or later. Details of the correlations of enzyme activity with clinical course have been presented elsewhere.^3-6

CPK and aldolase occur in multiple molecular forms called isoenzymes, which are separable by appropriate physicochemical methods.⁸ The type of CPK and aldolase present in . . . [Full Text PDF of this Article]

Author Affiliations
Chicago

From the Department of Psychiatry, University of Chicago Pritzker School of Medicine, and the Illinois State Psychiatric Institute.

Footnotes
Submitted for publication Dec 18, 1969.

Reprint requests to University of Chicago Pritzker School of Medicine, Department of Psychiatry, 950 E 59th St, Chicago 60637 (Dr. Meltzer).

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