 |
|
Carbohydrate Metabolism in ManiaBefore and After Lithium Carbonate Treatment
George R. Heninger, MD;
Peter S. Mueller, MD
Arch Gen Psychiatry. 1970;23(4):310-319.
|
|
| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
|
|
|
PREVIOUS reports from this laboratory1-3 have described in patients with severe depression an alteration in glucose metabolism which is characterized by resistance to both endogenous and exogenous insulin. This form of insulin resistance appears unlike that of any previously described medical illness and it disappears when the depression is successfully treated with amitriptyline (Elanil). In the course of these studies it was observed that after successful treatment of depression with amitriptyline, the manic-depressive patients demonstrated prolonged hypoglycemia in response to exogenous insulin. At the time of the test four of these six patients demonstrated manic symptoms. This suggested that, in contrast to the insulin resistance of severe depression, mania may be associated with an increased sensitivity to insulin.
To examine the possibility that increased insulin sensitivity and other alterations in glucose metabolism are associated with mania, we administered the standard intravenous glucose tolerance test (GTT) and insulin tolerance test
. . . [Full Text PDF of this Article]
Author Affiliations
New Haven, Conn
From the Department of Psychiatry, Yale University School of Medicine, the Connecticut Mental Health Center, New Haven.
Footnotes
Submitted for publication Nov 11, 1969.
Reprint requests to Connecticut Mental Health Center, PO Box 1842, 34 Park St, New Haven, Conn 06508 (Dr. Heninger).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
|
