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Results From a Collaborative Study

Robert F. Prien, PhD; Samuel L. DeLong, MD; Jonathan O. Cole, MD; Jerome Levine, MD; Chevy Chase, Md

Arch Gen Psychiatry. 1970;23(5):464-468.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

SINCE 1964 there have been numerous reports on lenticular and corneal opacities in patients treated with chlorpromazine.^1-9 These changes are well described in the literature. The lenticular opacities consist of granular deposits in the axial portion of the anterior capsule. When the change is mild, granules are small and assume a disciform distribution. In more advanced cases, the granules tend to accumulate along the suture lines and assume a stellate pattern with a dense central area and radiating branches. Corneal changes consist primarily of diffuse granular deposits at the posterior surface. In severe cases, the granularity may spread into the posterior third of the corneal stroma. These corneal changes rarely occur in the absence of lens change and appear to be proportional to the severity of the lens opacities.

Recently, opacities of the anterior cornea have been found in patients treated with chlorpromazine.^10,11 This change, . . . [Full Text PDF of this Article]

Author Affiliations
Washington, DC; Boston

From the Biometric Laboratory, George Washington University (NIMH-PRB Collaborative Studies on Chronic Schizophrenia), Washington, DC (Dr. Prien), Boston State Hospital (Boston) (Dr. Cole), and the Psychopharmacology Research Branch, National Institute of Mental Health, Chevy Chase, Md (Drs. Levine and Delong). Dr. Prien is currently with the Central Neuropsychiatric Laboratory, VA Hospital, Perry Point, Md.

Footnotes
Accepted for publication March 13, 1970.

Reprint requests to Central Neuropsychiatric Laboratory, Veterans Administration Hospital, Perry Point, Md 21902 (Dr. Prien).

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