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Herbert Y. Meltzer, MD; Ronald Moline, MD

Arch Gen Psychiatry. 1970;23(6):481-491.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

SERUM creatine phosphokinase (CPK) and aldolase activities are increased in many acutely psychotic patients of a variety of diagnostic types.^1-3 CPK exists in three molecular forms (isoenzymes). Type I is found almost exclusively in the brain, type II in cardiac muscle, and type III in skeletal and cardiac muscle.⁴ Much smaller amounts are present in many tissues.⁵ Only the type III isoenzyme of CPK was found in the sera of psychotic patients.^1,2 A number of possible causes of an increased activity in serum of type III CPK have been evaluated: orally or intramuscularly administered psychotropic medications^2,6; physical activity^2,7; severe emotional distress not part of a psychotic process² weight loss^2,8; hypersecretion of steroids² or epinephrine⁸; and muscle tension.⁷ These have been considered to be not responsible for the increased serum enzyme activity in most acutely psychotic patients. Increased activity of serum . . . [Full Text PDF of this Article]

Author Affiliations
Chicago

From the Department of Psychiatry, University of Chicago Pritzker School of Medicine (Dr. Meltzer), and the Illinois State Psychiatric Institute (Dr. Moline), Chicago.

Footnotes
Accepted for publication Jan 20, 1970.

Reprint requests to Department of Psychiatry, University of Chicago, 950 E 59th St, Chicago 60637 (Dr. Meltzer).

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