This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Joseph Mendels, MD; T. Alan Ramsey, MD; William L. Dyson, MD; Alan Frazer, PhD

Arch Gen Psychiatry. 1979;36(8):845-846.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Evidence has been accumulating from several sources in support of the claim that lithium is an effective antidepressant in a subgroup of depressed patients. The acceptance of this has been somewhat impaired by the availability of the tricyclic compounds that are relatively effective in a much larger number of depressed patients. Further, lithium's clear antimanic action has prompted resistance to the implications that a single compound is both antidepressant and antimanic.

The evidence for lithium's antidepressant action derives from 12 controlled studies that have been conducted in nine different centers (Table). Three of these^1-3 concluded that lithium was not an antidepressant, while the remaining nine^4-11 all reported a significant antidepressnat effect. These studies have been reviewed in detail else-where.^10,12,13

Also listed in this table is the most recent study from our group (T. A. Ramsey, MD, W. Dyson, MD, J. Mendels, MD, et al; unpublished findings, 1978), a single-blind study in . . . [Full Text PDF of this Article]

Author Affiliations
From the Affective Diseases Research Unit, Veterans Administration Hospital (Drs Mendel, Ramsey, and Frazer), and the Departments of Psychiatry (Drs Mendels, Ramsey, and Frazer) and Surgery (Dr Dyson), School of Medicine, University of Pennsylvania, Philadelphia.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?