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Some Biological Considerations

William E. Bunney, Jr, MD; Agu Pert, PhD; Jack Rosenblatt, MD; Candace B. Pert, PhD; Dorothy Gallaper, PhD

Arch Gen Psychiatry. 1979;36(8):898-901.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

This communication will review some of the properties of lithium and four possible cellular sites of interaction between lithium and other cations. It will emphasize the observation that lithium interacts with cyclic adenosine monophosphate (AMP)-mediated processes and, finally, will review a hypothesis that the onset of mania may be associated with the development of supersensitivity of catecholamine receptors. New evidence will be reported that lithium can block the development of supersensitivity in CNS neuronal receptors in rats.

PHYSICOCHEMICAL AND TRANSPORT CONSIDERATIONS

The major properties of lithium that determine its actions are size, charge, electrical field density, and energy of hydration. Lithium is the smallest alkali ion. It has the largest electrical field density at its surface and therefore has the largest energy of hydration (energy required to strip off water molecules). Lithium shares many properties with other periodic table group I as well as some group II metals. It competes with four cations most abundant in biological tissue (Na . . . [Full Text PDF of this Article]

Author Affiliations
From the Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Md. Dr. Rosenblatt is now with the Clinical Psychopharmacology Laboratory, NIMH, St Elizabeth Hospital, Washington, DC.

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