This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Elliot S. Gershon, MD
Section on Psychogenetics Biological Psychiatry Branch National Institute of Mental Health 9000 Rockville Pike Bethesda, MD 20205

Arch Gen Psychiatry. 1980;37(10):1200.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

I have been greatly puzzled over the discrepancy between the 1972 and 1974 pedigree series of Mendlewicz and colleagues^1,2 and the findings of myself and my colleagues³ that do not replicate the earlier findings. The Mendlewicz et al series clearly shows tight linkage between bipolar and related affective illness and the color blindness region on the X chromosome, and our series just as clearly rules out this linkage. Both series were collected in essentially the same population, 200 miles apart. Each series is homogeneous (one for linkage and one for nonlinkage) by Morton's test for homogeneity of lod scores (a linkage measure).4 Mendlewicz et al have recently suggested⁵ that there is genetic heterogeneity since his recent series has only one (of eight) pedigrees that strongly favors linkage, and this series is heterogeneous by Morton's test. But why, then, was his earlier series homogeneous? . . . [Full Text PDF of this Article]

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?