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Solomon C. Goldberg, PhD
Department of Psychiatry Medical College of Virginia MCV Station Box 710 Richmond, VA 23298

Elke D. Eckert, MD
Department of Psychiatry University of Minnesota Box 393 Mayo Minneapolis, MN 55455

Katherine A. Halmi, MD
Department of Psychiatry Cornell University Medical Center White Plains, NY 10605

Regina C. Casper, MD; John M. Davis, MD
Illinois State Psychiatric Hospital 1601 W Taylor St Chicago, IL 60625

Margaret Roper
Food and Drug Administration 5600 Fishers Lane Rockville, MD 20857

Arch Gen Psychiatry. 1980;37(9):1083.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

In an earlier publication¹ we reported the effects of cyproheptadine hydrochloride on weight gain in 81 anorexia nervosa patients. Cyproheptadine is a serotonin and histamine antagonist with anticholinergic and sedative effects. Since that time, we have completed the full sample of 105 patients and have found that cyproheptadine affects characteristics of anorexia nervosa other than body weight.

Females aged 10 to 40 years who met our study criteria for anorexia nervosa (an adaptation of those of Feighner et al²) were entered into a pretreatment period of seven days in hospital, after which they were randomly allocated to groups receiving combinations of (1) cyproheptadine or placebo, and (2) behavior modification or its absence, and followed up on these treatments in the hospital for 35 days. Aside from body weight, patients were evaluated periodically on a variety of symptoms, behaviors, and attitudes. This design was repeated in . . . [Full Text PDF of this Article]

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