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The Rate of Oxidation of N,N-Dimethyl-p-Phenylenediamine by Plasma and Levels of Serum Copper and Plasma Ascorbic Acid

JAMES W. MAAS, M.D.; GOLDINE C. GLESER, Ph.D.; LOUIS A. GOTTSCHALK, M.D.

Arch Gen Psychiatry. 1961;4(2):109-118.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

This study was undertaken in order to explore some of the factors which might contribute to rather consistent, but usually statistically nonsignificant, trends towards increased rates of oxidation of (DPP) N,N-dimethyl-p-phenylenediamine occurring in schizophrenics as compared to nonschizophrenics. Let us first briefly review the relevant investigations on this subject up to this time before further detailing our aims in this study.

In 1957 Akerfeldt demonstrated that the in vitro oxidation of DPP by serum, as measured by optical density at the end of a 6-minute period, is increased in patients with schizophrenia, senile psychoses, and manic-depressive illness.¹ He inferred that a reducing agent, most likely ascorbic acid, was responsible for the initial lag period, and that a catalytically active protein, possibly ceruloplasmin, a copper containing -globulin, was an important oxidizing agent. Holmberg and Laurell²⁴ noted that ceruloplasmin could oxidize many amines. . . . [Full Text PDF of this Article]

Author Affiliations
CINCINNATI

From the Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati General Hospital.

Present address: National Institute of Mental Health, Bethesda 14, Md. (Dr. Maas).

Footnotes
Submitted for publication July 21, 1960.

This study was supported by a research grant from the National Association for Mental Health, Inc. It was also supported, in part, by a research grant (MY-1055) from the U.S. Public Health Service, National Institute of Mental Health and a grant (T57-74) from the Foundations Fund for Research in Psychiatry.

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