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Mark Zimmerman; William Coryell, MD
University of Iowa Department of Psychiatry Iowa City, IA 52242

Arch Gen Psychiatry. 1985;42(2):200-201.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

In their multicenter investigation of the dexamethasone suppression test (DST), Stokes et al¹ found that nonsuppression (NS) was more frequent among healthy normal persons than has previously been reported, and that, among depressed patients, abnormal DST results were not significantly more frequent in endogenous, melancholic, or psychotic subtypes.

In placing their results in the context of the DST literature, Stokes et al reviewed only three other studies of the DST in healthy control subjects.^2-4 They attributed the low nonsuppression rates found by Carroll et al² and McHardy-Young et al³ to the fact that these investigators used 2 mg of dexamethasone. In contrast, Amsterdam et al⁴ used only 1 mg of dexamethasone and found a relatively high nonsuppression rate in healthy control subjects, similar to data obtained by Stokes et al.¹ Based on their own study and their limited literature review, Stokes et . . . [Full Text PDF of this Article]

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