
The Utility of the Dexamethasone Suppression Test-Reply
George W. Arana, MD
Department of Psychiatry Tufts University School of Medicine Boston Veterans Administration Medical Center Boston, MA 02130
Martin H. Teicher, MD, PhD;
Ross J. Baldessarini, MD
Department of Psychiatry Harvard Medical School Mailman Research Center McLean Hospital Belmont, MA 02178
Arch Gen Psychiatry. 1987;44(1):95-96.
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In Reply.—
In reflecting on correspondence and conversations following our recent review of the possible utility of the dexamethasone suppression test (DST) in psychiatry, we wish to make the following remarks and `amplifications. Certain evaluations pooled data from several studies to test for interesting trends by the use of 2 statistics.1 Janicak et al2 recommended the use of a more conservative 2 procedure developed by Mantel and Haenszel.3 We adapted their approach for use with a microcomputer and incorporated Yates' correction for small samples (the program is available from M.H.T.). The method computes a total 2 statistic by accumulating data from contingency tables arising from each study and decomposes this overall value into a 2 statistic of association testing the main effect, as influenced by the consistency of results across studies, as well as a statistic ( 2 for homogeneity) testing the consistency
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