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Michael Davidson, MD; Anne B. Giordani, MD; Richard C. Mohs, PhD; Thomas B. Horvath, MD; Bonnie M. Davis, MD; Peter Powchik, MD; Kenneth L. Davis
Department of Psychiatry Bronx Veterans Administration Medical Center and Mount Sinai School of Medicine 130 W Kingsbridge Rd Bronx, NY 10468

Arch Gen Psychiatry. 1987;44(2):189-190.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

Investigations in rodents demonstrated that short-term neuroleptic administration results in a rapid increment in the plasma homovanillic acid (pHVA) concentration, which is believed to reflect increased brain dopamine turnover.¹ Pickar et al² failed to demonstrate this acute neuroleptic-induced increase in the pHVA concentration in a group of schizophrenic patients.² As Pickar et al² correctly pointed out, we have also failed to detect changes in pHVA concentrations six hours after haloperidol administration.³ However, we would like to now report that there are robust increases in pHVA concentrations 24 hours after haloperidol administration.

Patients and Methods.—

Twenty-eight schizophrenic patients who were free of oral neuroleptics for at least three weeks and depot neuroleptics for at least three months participated in the study. Patients consumed a low-monoamine diet throughout the study and were fasting and at bed rest 14 hours before pHVA sampling. The pHVA . . . [Full Text PDF of this Article]

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