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Lars Farde, MD; Frits-Axel Wiesel, MD; HÅkan Hall, PhD; Christer Halldin, PhD; Sharon Stone-Elander, ,; Göran Sedvall, MD
Department of Psychiatry and Psychology Karolinska Institute S-104 01 Stockholm Sweden

Arch Gen Psychiatry. 1987;44(7):671-672.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

Densities of D₂ dopamine receptors in postmortem brain tissue from schizophrenic patients have been found to be higher than those in control brains.^1,2 The pathophysiologic significance of this finding has been questioned, since elevated receptor densities may be caused by neuroleptic treatment.³ It is now possible to examine D₂ dopamine receptor binding in the brains of living human subjects by means of new brain-imaging techniques and radiolabeled receptor ligands. Using a gamma camera and ⁷⁷Br-Bromospiperone, Crawley et al⁴ reported evidence of a slight increase in D₂ dopamine receptors in a group of schizophrenic patients. Using positron emission tomography (PET) and ¹¹CN-Methylspiperone, Wong et al⁵ recently reported a twofold to threefold elevation of D₂ dopamine receptor densities in the major basal ganglia of ten drug-naive and five previously treated schizophrenic patients. We previously used PET and . . . [Full Text PDF of this Article]

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