This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Robin McGregor Murray, MD, FRCP; Robert William Kerwin, MB, PhD
Institute of Psychiatry De Crespigny Park Denmark Hill London SE5 8AF England

Arch Gen Psychiatry. 1988;45(11):1052-1053.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

—We agree^1,2 with Weinberger that it is more appropriate to regard some schizophrenias as a remote consequence of an early brain lesion with subsequent neurodevelop mental deviance rather than as the result of an adult onset of a neurodegenerative disorder. However, we would like to discuss two points.

1. An early brain lesion is probably only one of a number of routes to the syndrome we currently call schizophrenia. To claim that it underlies all schizophrenia is to run the risk that the hypothesis will be discounted because not all schizophrenics conform to its predictions. The neurodevelopmental model is certainly compatible with recent neuropathologic findings and with those computed tomographic (CT) scan studies that demonstrate an association between a complicated pregnancy and birth, later schizophrenia, and enlarged cerebral ven tricles.^1,3,4 It also provides an explanation for the deviant childhood behavior found in a proportion of schizophrenics and for . . . [Full Text PDF of this Article]

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?