This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (8)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Samuel G. Siris, MD
Department of Psychiatry Mount Sinai School of Medicine KCC 1 South PO Box 1228 New York, NY 10029

Arch Gen Psychiatry. 1988;45(11):1055.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

In his article, published in the July 1987 issue of the Archives, Weinberger¹ presents an intriguing and heuristically rich model of hypothesized interaction between prefrontal cortical and mesolimbic dopamine systems in schizophrenia. This model is consistent with a great deal of evidence that has accumulated with regard to schizophrenia, including, crucially, the timing of its onset in terms of developmental maturation within the central nervous system. Weinberger's is the latest of a series of structural versions of the "diathesis" in the stress-diathesis model of schizophrenia.²

Weinberger notes that the structural lesion in such a model does not necessarily imply the existence of a distinct, discontinuous biologic subgroup. The "schizophrenia lesion" in such a model could possibly be no more than the extreme end of a developmental spectrum with regard to the organization of a particular central nervous system functional system, such as the hypothesized abnormality . . . [Full Text PDF of this Article]

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?