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Philip Seeman, MD, PhD
Department of Pharmacology Medical Sciences Building University of Toronto Toronto, Canada M5S 1A8

Arch Gen Psychiatry. 1988;45(6):598-599.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

Using a radioactive neuroleptic selective for D₂ dopamine receptors, Farde et al¹ found no difference in the brain striatal densities of these receptors between schizophrenics and control subjects, as monitored by positron emission tomography (PET). It may be important to note that the absolute values for the control D₂ densities in that study¹ were much higher than those measured in previous PET studies^2,3 or in vitro.⁴ This is indicated in Fig 1, which illustrates that the human in vitro D₂ densities are between 12.5 ±0.6 pmol/g (mean ± SEM) for caudate nucleus and 14.3 ±0.8 pmol/g for putamen (N = 29; mean [±SEM] age, 34.4 ±6.6 years; using tissues from subjects 20 to 40 years of age⁴). Thus, the high value of 24.6 pmol/mL (or 23.9 pmol/g, since the specific gravity of human striatum . . . [Full Text PDF of this Article]

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