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Edward R. Ritvo, MD; Anne Mason-Brothers
Division of Mental Retardation and Child Psychiatry

John H. Menkes, MD
Departments of Neurology and Pediatrics

Robert S. Sparkes, MD
Department of Medicine UCLA School of Medicine Los Angeles, CA 90024

Arch Gen Psychiatry. 1988;45(6):600.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

We wish to report the simultaneous occurrence of autism, sporadic retinoblastoma, reduced esterase D activity, and a deletion on chromosome 13 in a 19-year-old woman with an autistic maternal second cousin.

The patient was born following an apparently normal pregnancy and delivery. She was identified as developmentally delayed by the end of her first year of life. At age 2Vz years, a retinoblastoma of the right eye was removed by enucleation. No radiation was given, and her left eye remained uninvolved. The diagnosis of autism was established by repeated developmental, psychiatric, psychologic, and educational assessments (DSM-III¹ and National Society for Autistic Children² criteria). Mental status examination by one of us (E.R.R.) confirmed the diagnosis of autism, full syndrome present (DSM-III 299.0).¹ The red blood cell esterase D level was 50% normal, and trypsin-Giemsa chromosome banding analysis revealed a deletion on the long arm of . . . [Full Text PDF of this Article]

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