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Biochemical Classifications of Diagnostic Subgroups and D-Type Scores
William Z. Potter, MD, PhD;
Markku Linnoila, MD, PhD
Arch Gen Psychiatry. 1989;46(3):269-271.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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The article by Schatzberg et al1 in this issue of the ARCHIVES on the "D-score" reflects an unusually impressive and sustained effort. This work was initiated by Dr Joseph Schildkraut2 who is well known for providing one of the earliest formulations of the catecholamine hypothesis of affective disorders. The D-type score was the result of a discriminant function analysis of urinary catecholamine metabolites carried out with a stepwise entry of variables in the order in which they contributed to discriminating between a small group of bipolar manic-depressive and unipolar chronic charactrological depressions. Dr Schildkraut and Schatzberg and colleagues had observed that a single urinary catecholamine metabolite, 3-methoxy-4-hydroxyphenylglycol (MHPG), was by itself present in a significantly lower concentration in the bipolar than unipolar chronic characterological depressions and then considered the important possibility "that the other urinary metabolites might also contain information that would be useful in differentiating these two
. . . [Full Text PDF of this Article]
Author Affiliations
From the Section on Clinical Pharmacology, Laboratory of Clinical Science, National Institute of Mental Health (Dr Potter), and the Laboratory of Clinical Studies, DICBR, National Institute on Alcohol Abuse and Alcoholism (Dr Linnoila), Bethesda, Md.
Footnotes
Accepted for publication Sept 27, 1988.
Reprint requests to National Institutes of Mental Health, Building 10, Room 2046, Bethesda, MD 20892 (Dr Potter).
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