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Elevated Levels of Soluble Interleukin 2 Receptors in Schizophrenia
Mark Hyman Rapaport, MD;
Cathy G. McAllister, PhD;
David Pickar, MD
Clinical Neuroscience Branch National Institute of Mental Health Bldg 109, Room 4N-212 9000 Rockville Pike Bethesda, MD 20892
David L. Nelson, MD
Immunophysiology Section Metabolism Branch National Cancer Institute Bldg 10, Room 4N-112 9000 Rockville Pike Bethesda, MD 20892
Steven M. Paul, MD
Clinical Neuroscience Branch National Institute of Mental Health Bldg 10, Room 4N-224 9000 Rockville Pike Bethesda, MD 20892
Arch Gen Psychiatry. 1989;46(3):291-292.
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To the Editor —
Immunologic factors have been implicated in both the cause
 Levels of soluble interleukin 2 (IL-2) receptor in the serum of schizophrenic patients and healthy controls. Soluble IL-2 receptors were measured by a sandwich enzymelinked immunosorbent assay as previously described.7 Each point represents the value for one subject; 1 U is approximately 3 pg of soluble IL-2 receptor. Schizophrenic patients (N = 30) were diagnosed using DSMIII and Research Diagnostic Criteria. The horizontal line indicates 2 SDs above the mean value for healthy controls; asterisk, P<.001 compared with controls (N =13) by Student's t test. and pathogenesis of schizophrenia, and alterations in immune measures, such as serum and cerebrospinal fluid immunoglobulin levels, circulating B and T lymphocytes, and the presence of anti—brain autoantibodies, have been reported by some but not all laboratories.1 Problems in demonstrating consistent immunologic stigmata in schizophrenia may
. . . [Full Text PDF of this Article]
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