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Rohan Ganguli, MD; Bruce S. Rabin, MD, PhD
Departments of Psychiatry and Pathology School of Medicine University of Pittsburgh Pittsburgh, PA 15261

Arch Gen Psychiatry. 1989;46(3):292.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

It has been suggested that autoimmunity may play a role in the pathogenesis of symptoms in some schizophrenics.^1,2 Activation of the immune system by an ongoing autoimmune disease is associated with measurable alterations in T-lymphocyte function. In patients with an autoimmune disease, T lymphocytes have a decreased response to nonspecific mitogenic stimulation and produce reduced amounts of interleukin 2 (IL-2).^3-5 As IL-2 is necessary for T lymphocytes to respond in a normal manner to nonspecific mitogens, the reduced mitogenic activity may reflect low IL-2 production by the T cells.

Recently it has been suggested that the low lymphocyte production of IL-2 in patients with an autoimmune disease occurs because the T cells are activated and the lymphocyte-derived IL-2 has been released into the serum.⁶ Alternatively, the IL-2 released from lymphocytes may be bound by soluble IL-2 receptor (IL-2R) released from the cell surface. If . . . [Full Text PDF of this Article]

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