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Robert F. Prien, PhD; David J, Kupfer, MD

Arch Gen Psychiatry. 1989;46(5):462-464.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The report by Shapiro et al¹ in this issue of the ARCHIVES raises a number of issues regarding multicenter collaborative studies and their analyses. Our general comments pertain primarily to publicly funded collaborative trials. Multicenter studies sponsored by pharmaceutical companies or other private sources raise a different set of issues that are discussed elsewhere.²

See also pp 397 and 401.

The report by Shapiro et al¹ stemmed from a request from the authors to reanalyze data from the National Institute of Mental Health (NIMH) (Rockville, Md) Collaborative Study on Maintenance Drug Therapy in Affective Disorders³ by using a life-table regression model. The authors had not participated in the collaborative study or in the preparation of earlier reports of findings. Their results demonstrate that large collaborative studies can benefit from infusion of different analytic approaches from outside the collaborative study group. Unfortunately, some multicenter collaborative projects often . . . [Full Text PDF of this Article]

Author Affiliations
From the Affective and Anxiety Disorders Research Branch, Division of Clinical Research, National Institute of Mental Health, Rockville, Md (Dr Prien); and the Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh (Dr Kupfer).

Footnotes
Accepted for publication Aug 8, 1988.

Reprint requests to National Institute of Mental Health, Room 10C-24, Parklawn Bldg, 5600 Fishers Lane, Rockville, MD 20857 (Dr Prien).

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