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Adam Wolkin, MD; Jonathan D. Brodie, PhD, MD; Fauozia Barouche, MD; John Rotrosen, MD
Department of Psychiatry New York University Medical Center 550 First Ave New York, NY 10016

Alfred P. Wolf, PhD; Michael Smith, MD; Joanna Fowler, PhD
Department of Chemistry Brookhaven National Laboratory Upton, NY 11973

Thomas B. Cooper, MA
Nathan Kline Institute, Orangeburg, NY 10962

Arch Gen Psychiatry. 1989;46(5):482-483.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

The kinetics of receptor-ligand interaction predict a curvilinear relationship between free brain ckade (inset). 6 5 4 in 3 2 e d c e a m x o p p A i 0 10 20 30 40 50 60 Plasma Haloperidol Level, ng/mL 20 40 60 80 100 Plasma Haloperidol Level, ng/mL ligand concentration or neuroleptic plasma level and dopamine receptor occupancy. Based on positron emission tomography (PET) studies using 11C-raclopride in several subjects, Farde et al1 recently presented a theoretical binding curve for this relationship. Cambon et al² derived a similar curvilinear relationship from 76Br-labeled bromospiperone PET scans of six subjects who had varying diagnoses and were receiving either haloperidol or thioproperazine.

We conducted similar studies using the D2 radioligand 18F-j!V methylspiperone (NMS) to estimate dopamine receptor availability in patients with schizophrenia. Subjects included patients who were not receiving neuroleptic therapy and others who were treated . . . [Full Text PDF of this Article]

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