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James Finkelstein, MD
Fordham-Tremont Community Mental Health Center 2021 Grand Concourse Bronx, NY 10453

Arch Gen Psychiatry. 1989;46(9):859.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

Ehlers and colleagues,¹ in an article in the October 1988 issue of the ARCHIVES, suggest that psychosocial factors act as zeitgebers in the entrainment of circadian rhythms, and that it is the disruption of this process and subsequent desynchronization of the rhythms that are responsible for clinical depression in vulnerable individuals. This is a powerful and fascinating theory. All of us hope for reasonable and useful theoretical models that connect the psychosocial with the biological. The article leaves this reader with certain questions.

1. The authors point out that modern biological research on depression first established that depression is associated with decreased levels of serotonin and norepinephrine in the synaptic clefts of certain portions of the central nervous system and more recently has shifted to studies of neuroendocrine dysregulation. Since we know that the lowered levels are real, they have to be connected in some . . . [Full Text PDF of this Article]

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