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Arthur Margolin, Phd; Thomas Kosten, MD; Ismene Petrakis, MD; S. Kelly Avants, MS; Therese Kosten, Phd
Substance Abuse Treatment Unit Department of Psychiatry Yale University School of Medicine 9141/2 Howard Ave New Haven, CT 06519

Arch Gen Psychiatry. 1991;48(1):87.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

Cocaine abuse is a major problem among methadonemaintained patients.¹ We recently tested the "second generation" antidepressant bupropion with six cocaine-dependent, methadone-maintained patients in an 8-week open pilot study. A test of the drug for the treatment of cocaine dependence was suggested by research showing that it directly influences dopaminergic transmission² and because it possesses few of the cardiovascular and anticholinergic side effects of "first generation" antidepressants.³

Patients and Methods.—

Six methadonemaintained patients participated in the study (two males and four females; mean [±SD] age, 35 ±11 years; daily mean [±SD] methadone dosage, 60 ±20 mg). All subjects were chronic intravenous cocaine users (mean [ ± SD] years of cocaine use, 12 ±8.2 years) who had used at least 0.5 g of cocaine per week for 3 months previous to entry into the study. All met DSM-III-R criteria for cocaine dependence. Subjects received 100 mg . . . [Full Text PDF of this Article]

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