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Lori L. Altshuler, MD
Department of Psychiatry and the Biobehavioral Sciences UCLA Neuropsychiatric Hospital 740 Westwood Blvd Los Angeles, CA 90266

Andrew Conrad, PhD
Department of Anatomy and Cell Biology UCLA School of Medicine Center for Health Sciences Los Angeles, CA 90024

Peter Hauser, MD
Biological Psychiatry Branch National Institute of Mental Health Bethesda, MD 20892

Ximing Li, MD
Department of Neurology UCLA School of Medicine Center for Health Sciences Los Angeles, CA 90024

Barry H. Guze, MD
Department of Psychiatry and the Biobehavioral Sciences UCLA Neuropsychiatric Hospital 740 Westwood Blvd Los Angeles, CA 90266

Kirk Denikoff, MD
Biological Psychiatry Branch National Institute of Mental Health Bethesda, MD 20892

Wallace Tourtellotte, MD, PhD
Department of Neurology Wadsworth VA Hospital Wilshire and Sawtelle Blvds Los Angeles, CA 90025

Robert Post, MD
Biological Psychiatry Branch National Institute of Mental Health Bethesda, MD 20892

Arch Gen Psychiatry. 1991;48(5):482-483.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

We recently reported¹ that ratios of temporal lobe area to cerebrum area determined by magnetic resonance imaging (MRI) were significantly smaller in patients with primary affective disorder than in normal controls. While the results suggested temporal lobe abnormalities in the patients with affective disorder, only one coronal slice through each middle temporal lobe was examined. We report preliminary findings of total temporal lobe volume in 10 patients with bipolar disorder and in 10 normal controls.

Subjects and Methods.—

Ten patients meeting Research Diagnostic Criteria for bipolar disorder were studied. All patients had bipolar I disorder; six patients were from a previous study.¹ The remaining four patients had been admitted for inpatient or outpatient services at the Biological Psychiatry Branch of the National Institute of Mental Health since the previous report. The total group included five men and five women, aged 30 to 58 years (mean, . . . [Full Text PDF of this Article]

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