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Wade H. Berrettini, MD, PhD
Department of Psychiatry Jefferson Medical College 1015 Walnut St, Room 312 Philadelphia, PA 19107

Elliot S. Gershon, MD; Lynn R. Goldin, PhD; Pablo V. Gejman, MD; Sevilla Detera-Wadleigh, PhD
Bethesda, Md

Joel Gelernter, MD
New Haven, Conn

Arch Gen Psychiatry. 1991;48(7):673-675.

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The hypothesis of X-linked manic-depressive illness is a general hypothesis not restricted to pedigrees without apparent male-tomale transmission. Risch et al,¹ in their analysis of our published family study of a large series of subjects with bipolar affective disorder unselected for sex or type of illness in relatives, concluded that our data were compatible with a significant proportion of cases of X-linked transmission (25% of males with bipolar [BP] illness and 40% of females with BP illness). The exclusion of families with apparent male-to-male transmission is a way of enriching a pedigree series for the X-linked proportion (if there is population genetic heterogeneity), and we excluded pedigrees with ill father-son pairs for this reason.

In a common disease, it is probable that at least one case of illness will appear among relatives of well people if enough relatives are studied. For example, when studying first-degree relatives of 50 psychiatrically . . . [Full Text PDF of this Article]

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