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  Vol. 48 No. 8, August 1991 TABLE OF CONTENTS
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Association Between the D2 Dopamine Receptor Gene and Alcoholism

A Continuing Controversy

P. Michael Conneally, PhD

Arch Gen Psychiatry. 1991;48(8):757-759.

Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The idea that alcoholism is familial has been accepted for centuries. However, familial does not translate directly to hereditary. Studies on twins, raised together and apart (adoption studies), clearly show that there is a major genetic component to alcoholism. In fact, more recent studies on a total of 1775 children born to single mothers in Stockholm, Sweden, between 1930 and 1949, their adoptive families, and their biological parents have identified at least two of the following classes of alcoholics: milieu-limited (type 1) and malelimited (type 2). Although type 2 alcoholism is more frequent in men, their female siblings show an abnormally high prevalence of somatization disorder. Type 2 alcoholism is highly inheritable from father to son, regardless of environmental background. On the other hand, in the Swedish adoption study, the risk of type 1 alcoholism to siblings increased as a function of both biological family history and adoptive environment.1 . . . [Full Text PDF of this Article]


Author Affiliations

Indianapolis, Ind



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