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James S. Brown, Jr, MD
Department of Psychiatry Walter Reed Army Medical Center Washington, DC 20307-5001

Arch Gen Psychiatry. 1992;49(5):416.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

Recent studies by Pettegrew et al¹ and Williamson et al² provide exciting opportunities for furthering the understanding of schizophrenia. Using magnetic resonance imaging, both groups found reduced levels of phosphomonoesters (PME) in the prefrontal cortex of the brains of schizophrenic patients; however, only Pettegrew et al¹ found elevated phosphodiester (PDE) levels in the same region. Williamson et al² found PDE levels to be normal. Five of the 11 patients studied by Pettegrew et al¹ had paranoia. Unfortunately, Williamson et al² did not provide diagnostic classification.

Diagnostic information may be important in that Gattaz³ found in- creased phospholipase A2 activity in schizophrenics. Pettegrew et al¹ referred to this finding when suggesting causes of increased PDE levels but failed to mention that all of Gattaz's patients had paranoia. Considering that Williamson et al² did not find increased PDE levels, it . . . [Full Text PDF of this Article]

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