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Jay W. Pettegrew, MD
University of Pittsburgh 130 DeSoto St, Room A736 Crabtree Hall/GSPH Pittsburgh, PA 15261

Matcheri S. Keshavan, MD; Kanagasabai Panchalingam, PhD
Pittsburgh, Pa

Arch Gen Psychiatry. 1992;49(5):417.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In Reply. —

Brown raises a very in- teresting point; that is, do the brain PME and PDE levels in schizophrenic patients correlate with the clinical subtype? In our preliminary report,¹ there were five paranoid and six undifferentiated schizophrenic patients.

There were no significant differences in PME and PDE levels (mean± SD) among the control(PME, 20.25±2.97 mol %; PDE, 32.20±1.96. mol %), paranoid (PME, 14.77±2.28 mol %; PDE,38.52±5,58 mol %), and undifferentiated (PME, 16.05±3.49 mol %; PDE, 34.70±4.06 mol %) schizophrenic patients in this small sample, although the PDE levels were higher and PME levels lower in the paranoid patients. Perhaps with a larger sample, a difference between paranoid and undifferentiated patients will be observed.

A more likely explanation for the difference between the PME and PDE findings in our preliminary study and those reported by Williamson et al² is that our patients were "first-break, never-medicated" and those studied by Williamson et al were patients . . . [Full Text PDF of this Article]

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