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Michel Maziade, MD
Centre de Recherche Université Laval Robert-Giffard 2601 de la Canardiére Beauport, Québec, Canada G1J 2G3

Marc Debraekeleer, MD
Chicoutimi, Québec

Paul Genest, PhD
Sainte-Foy, Québec

Denis Cliche, MD; Jean-Pierre Fournier, MD; Yvon Garneau, MD; Christian Shriqui, MD; Marc-André Roy, MD; Luc Nicole, MD; Vincent Raymond, MD, PhD
Beauport, Québec

Michel Vekemans, MD
Montréal, Québec

Arch Gen Psychiatry. 1993;50(1):73-75.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

A search for the concurrence of cytogenetic anomalies and major psychiatric disorders transmitted within the same family is certainly warranted to save time and resources

III Pedigree 218 Pedigree 218. Solid squares represent schizophrenia as defined by DSM-III-R5; shaded squares, alcohol dependence (DSM-III-R); and asterisk, balanced translocation t(2:18) (p11.2, p11.2). in the process of identifying genes that predispose to major psychoses.¹ The extremely rare and striking occurrence of these two phenomena transmitted within the same family has been reported on different occasions.^2,3 However, the leads provided by these reports should be taken with caution if there is a small number of clearly affected subjects in the pedigree under scrutiny² or if there is a lack of specificity of the disorders associated with the karyotypic anomaly.³

In the process of screening multiplex families densely affected by schizophrenia in Eastern Québec, Canada,⁴ we detected . . . [Full Text PDF of this Article]

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