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J. Dee Higley, PhD
Laboratory of Clinical Studies National Institute of Alcohol Abuse and Alcoholism National Institutes of Health Animal Center Bldg 112, PO Box 289 Poolesville, MD 20837

Patrick T. Mehlman, PhD; David Taub, PhD
Laboratory Animal Breeders and Services Yemassee, SC

Stephen J. Suomi, PhD; Sue B. Higley
Laboratory of Comparative Ethology National Institute of Child Health and Human Development Bethesda, Md

James M. Vickers, DVM
Pathobiology and Primatology Laboratory Food and Drug Administration Bethesda, Md

Markku Linnoila, PhD, MD
Office of the Scientific Director National Institute of Alcohol Abuse and Alcoholism Bethesda, Md

Arch Gen Psychiatry. 1994;51(1):73.

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Dr Reus criticizes as "overstated" and "critically dependent on one subject" our reporting of a significant relationship between CSF 5-HIAA concentrations and aggression. We note that even when the single subject in question is dropped from the analysis, the results remain statistically significant (r=.46, P<.05). While our study is the first, to our knowledge, to correlate interindividual differences in CSF 5-HIAA with aggression in nonhuman primates, our primary hypothesis of a negative correlation between aggression and CSF 5-HIAA was based on other cited studies of nonhuman primates, showing that increasing or decreasing serotonin activity pharmacologically produces the decrease or increase in aggression, respectively.

In a follow-up study of these subjects, we extended this initial finding. We reported at the meeting of the American Society of Primatology¹ that when direct behavioral observations of these animals are collected, they are more impulsive and engage in aggressive acts with a high likelihood of . . . [Full Text PDF of this Article]

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