This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

John H. Krystal, MD
National Center for Posttraumatic Stress Disorder West Haven Veterans' Affairs Medical Center West Haven, CT 06516

Steven M. Southwick, MD; Dennis S. Charney, MD
West Haven

Arch Gen Psychiatry. 1994;51(5):430.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In reply

We appreciate Dr Wiseman's effort to highlight the possible neurobiological significance of substance abuse for patients with PTSD and panic disorder. Similar to the clinical reports on patients with panic disorder that she cited, we and others previously described cases in which acute alcohol or opiate withdrawal exacerbated PTSD symptoms in dually diagnosed patients.^1,2

The hypothesis that activation of noradrenergic systems might increase panic or PTSD symptoms was studied in a series of investigations using the ₂-adrenergic antagonist, yohimbine. We found that this drug elicited panic attacks in some patients with panic disorder and PTSD, but not in healthy subjects or patients with other major psychiatric disorders including generalized anxiety disorder, major depression, and schizophrenia.^3,4

While it is likely that the cycle of alcohol consumption and withdrawal affects the course of panic disorder and PTSD, there is little evidence to support the hypothesis that subacute alcohol . . . [Full Text PDF of this Article]

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?