This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (7)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Robert W. McCarley, MD; Martha E. Shenton, PhD; Brian F. O'Donnell, PhD; Paul G. Nestor, PhD
Neuroscience Laboratory Department of Psychiatry Harvard Medical School and the Brockton/West Roxbury Veterans Affairs Medical Center Brockton, MA 02401

Arch Gen Psychiatry. 1994;51(7):515-516.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

T point made in the article by Carpenter et al¹ about the need for multiple assessment modalities in differentiating the neural circuits that are abnormal in subgroups of the schizophrenia syndrome is well taken. However, an important and well-documented neural circuit is omitted in their compilation of the "predicted pattern of neural circuit involvement" for subtypes of schizophrenia. There are strong data indicating that the neocortical superior temporal gyrus (STG) is a key circuit related to positive symptoms ("nondeficit schizophrenia," using the terminology of Carpenter et al¹), with abnormalities being linked to auditory hallucinations, thought disorder, certain memory tasks, and altered metabolic and electrophysiological functional activity.

The presence of auditory hallucinations has been found to be associated with both structural and metabolic STG abnormalities. Barta et al² report correlations with magnetic resonance imaging volume reductions and Cleghorn et al³ note correlations with abnormal regional metabolism in a fluorodeoxyglucose . . . [Full Text PDF of this Article]

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?