This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Hans C. Breiter, MD
OCD Clinic-CNY-9 Massachusetts General Hospital Charlestown, MA 02129

Pauline A. Filipek, MD; David N. Kennedy, PhD; Lee Baer, PhD; Dawn A. Pitcher; Michael J. Olivares
Boston, Mass

Perry F. Renshaw, MD, PhD
Belmont, Mass

Verne S. Caviness, Jr, MD, DPhil; Michael A. Jenike, MD
Boston, Mass

Arch Gen Psychiatry. 1994;51(8):663-664.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Many studies have implicated the orbital gyrus and caudate nucleus as factors in obsessive-compulsive disorder (OCD).¹ However, several recent neuropsychological and positron emission tomographic imaging studies have suggested that posterior parts of the brain may also be involved.^2-6 Based on these findings, it is possible that OCD symptoms might result from a problem with higher-level perceptual Processing in the retrocallosal region, which could have an underlying structural substrate.

To study this hypothesis, using morphometric volume analysis of the retrocallosal region, we performed magnetic resonance imaging (MRI) scans of six female patients with OCD and eight female controls matched for age (mean±SD age of patients: 30.8±5.7 years; range, 20 to 37years; mean age of controls: 27.3±5.3 years; range, 17 to 33 years), handedness, and education (five of six OCD patients had a college or graduate education; all controls had a college or graduate education). The patients had been moderately . . . [Full Text PDF of this Article]

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?