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Gabriel Safadi, MD
Department of Psychiatry Charles LeMoyne Hospital 121 Taschereau Blvd Greenfield Park, Quebec, Canada J4V 2H1

Jacques Bradwejn, MD
Montreal, Quebec

Arch Gen Psychiatry. 1995;52(1):76-77.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

We read with interest the article by Southwick et al¹ in the April 1993 issue of the ARCHIVES. Using intravenous yohimbine hydrochloride, the authors induced panic attacks in 70% and flashbacks in 40% of 20 subjects suffering from chronic posttraumatic stress disorder (PTSD). It is unclear, however, if their conclusion that panic disorder and PTSD share a common neurobiology is not, at least in part, a reflection of a lack of specificity in their assessment procedure. Furthermore, the applicability of their findings to the majority of people suffering from PTSD needs to be questioned.

Rainey et al² reported the effect of intravenous lactate in seven Vietnam veterans with a history of flashbacks, six of whom met DSM-III criteria for both PTSD and panic disorder, and one with a history of PTSD meeting DSM-III criteria for panic disorder at intake. All of these subjects reported flashbacks after lactate infusion. . . . [Full Text PDF of this Article]

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