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David A. Nielsen, PhD; David Goldman, MD
Laboratory of Neurogenetics Division of Intramural Clinical and Biological Research National Institute on Alcohol Abuse and Alcoholism Flow Building, Room 2 12501 Washington Ave Rockville, MD 20852

Matti Virkkunen, MD; Riitta Tokola, MD; Helsinki Finland; Robert Rawlings, MS; Markku Linnoila, MD, PhD
Bethesda, Md

Arch Gen Psychiatry. 1996;53(10):964-965.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

WE reported a population association between a tryptophan hydroxylase (TPH) intron 7 polymorphism with suicidal behavior in Finnish alcoholic offenders and with cerebral spinal fluid 5-hydroxyindoleacetic acid concentration in impulsive offenders.¹ Abbar et al² found no association between a different TPH polymorphism and suicidal behavior in a clinically and ethnically divergent sample. Our TPH association was presented as a preliminary result requiring replication. However, the study by Abbar et al² has little relevance to the validity of the association we observed. They used a different, unpublished TPH marker to genotype both women and men who were undergoing psychiatric care and who had a dissimilar and mixed diagnostic profile and a different ethnic background. Therefore, the assertion by Abbar et al of a "discrepancy" between their and our results has no basis.

The Ava II restriction fragment length poIymorphism used by Abbar et al² is distinct from . . . [Full Text PDF of this Article]

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