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Jay W. Pettegrew, MD; Matcheri S. Keshavan, MD
Department of Psychiatry Western Psychiatric Institute and Clinic 3811 O'Hara St Pittsburgh, PA 15213

Arch Gen Psychiatry. 1997;54(2):187-188.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

This is an interesting and informative case report that demonstrates changes in brain membrane phospholipid metabolism in a young subject with HD. The changes observed in the subject with HD are similar to the changes previously reported in subjects with schizophrenia.^1-3 The in vivo³¹P MRS findings in the subject with HD are consistent with earlier in vitro³¹P MRS findings on autopsy brain samples of subjects with HD that revealed changes in membrane phospholipid metabolism.⁴ The young subject with HD had clinical and molecular features that were similar to young subjects with schizophrenia.

The findings of decreased phosphomonoester concentrations in this subject with HD and the previously reported subjects with schizophrenia probably reflect changes in the neuropil. These changes could be due to the following: (1) reduced neuropil development (ie, an early neurodevelopmental insult), (2) exaggerated synaptic pruning of a normal neuropil (ie, a late . . . [Full Text PDF of this Article]

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