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The Impact of Perphenazine and of Placebo

PETER A. MOLLING, M.D.; ARTHUR W. LOCKNER, JR., M.S.W.; ROBERT J. SAULS, M.S.W.; LEON EISENBERG, M.D.

Arch Gen Psychiatry. 1962;7(1):70-76.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

This paper reports on a pilot investigation designed to test the effectiveness of perphenazine and placebo in producing changes in the behavior of a group of institutionalized Negro delinquent boys.

Review of Literature

In a study of 777 delinquents evaluated at the Judge Baker Foundation Clinic, the Gluecks classified 13% as showing "mental disease or distortion" and an additional 41% as exhibiting "marked personal liabilities or adolescent instability."¹ There is evidence to suggest that such a population breeds criminality² and mental illness.^3,4 The psychopathology reported in delinquent children usually includes aggressivity, impulsiveness, overactivity, and neurotic symptomatology, all of which have been listed as indications for ataractic drugs. Psychiatrists are being asked with increasing frequency to provide guidance for the management of emotionally disturbed children in the training school. Yet, the literature reflects a paucity of adequately controlled studies with delinquents, and we . . . [Full Text PDF of this Article]

Author Affiliations
BALTIMORE

Children's Psychiatric Service, Harriet Lane Home, The Johns Hopkins Hospital.

Instructor in Pediatrics and Psychiatry, The Johns Hopkins University School of Medicine (Dr. Molling); Instructor in Pediatrics, The Johns Hopkins University School of Medicine (Mr. Lockner); Professor of Child Psychiatry, The Johns Hopkins University School of Medicine (Dr. Eisenberg); Assistant Superintendent, Boys' Village of Maryland, Cheltenham, Md. (Mr. Sauls).

Footnotes
Submitted for publication July 7, 1961.

This pilot investigation is part of a series of psychopharmacological studies supported by the National Institute of Mental Health (Grant MY-2583 to Leon Eisenberg, M.D. and Sonia F. Osler, Ph.D).

Presented at the 1961 Annual Meeting of the American Psychiatric Association.

Placebo and Perphenazine were supplied by the Schering Corporation.

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