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Mental Stress, Blood Proteins, and the HypothalamusExperimental Results Showing Effect of Mental Stress upon 4S and 19S Proteins: Speculation That the Functional Behavior Disturbances May Be Expressions of a General Metabolic Disorder
W. J. FESSEL, M.R.C.P.
Arch Gen Psychiatry. 1962;7(6):427-435.
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This paper has 3 purposes: (1) to report an experiment which showed that severe mental stress caused a rise in serum levels of 4S and 7S class proteins; (2) to review the literature concerning the effect of mental stress and disturbances of the diencephalon and hypothalamus upon the blood proteins and the immunological mechanisms; (3) to posit that the functional psychosis is but one expression of a general metabolic disorder which is contributed to by the effects of both stress and hypothalamic-hypophyseal action.
The finding of abnormal serum proteins in so-called functional psychoses was documented and extensively reviewed in previous communications.12-17 It seemed likely that these abnormalities might be connected intimately with the genesis of the psychosis, since they were seen in a group of acutely mentally disturbed patients very early in the course of their illness and before they had received drug or electroshock therapy.12,14,15 It
. . . [Full Text PDF of this Article]
Author Affiliations
(LOND. AND EDIN.) SAN FRANCISCO
Footnotes
Submitted for publication Jan. 23, 1962.
The Langley Porter Neuropsychiatric Institute, California Department of Mental Hygiene, and the Departments of Psychiatry and Medicine, University of California School of Medicine, San Francisco.
The work was supported by grants from the California Department of Mental Hygiene and the National Institute of Mental Health (MY-4581).
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