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Motor Activity in SchizophreniaEffect on Plasma Factor
CHARLES E. FROHMAN, PhD;
L. K. LATHAM;
K. A. WARNER;
C. O. BROSIUS, MD;
P. G. S. BECKETT, MD;
J. S. GOTTLIEB, MD
Arch Gen Psychiatry. 1963;9(1):83-88.
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Introduction
In a number of previous reports1-3 data have been presented showing that when chicken erythrocytes are incubated in plasma from patients with schizophrenia the ratio of lactate to pyruvate remaining in the medium is significantly higher than the ratio obtained using plasma from control subjects. On the average, patients' plasma gives a ratio approximately twice as great as the ratio derived from the study of control subjects. This difference in lactate/pyruvate (L/P) ratio between control and schizophrenic plasma is apparently caused by a substance in plasma, probably a protein.3,4 At present this substance has not been completely identified, so that it is unknown whether it is a normal substance in excessive amount, or an abnormal one.
While the chicken cell method differentiates between groups of schizophrenic and nonschizophrenic subjects, there is overlap in the distributions of the L/P ratios between the two groups.
. . . [Full Text PDF of this Article]
Author Affiliations
DETROIT
From the Lafayette Clinic and Northville State Hospital, and Wayne State University College of Medicine.
Footnotes
Submitted for publication Sept 21, 1962.
This investigation was supported in part by grants MY 4816 from the National Institute of Mental Health, The Scottish Rite Committee on Research, and the Research Foundation of the National Association for Mental Health.
Examples of the day-to-day chicken cell L/P ratios for control and schizophrenic subjects are presented in Table 7.
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