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ARNOLD J. MANDELL, MD; GRANT SLATER, PhD; ROBERT H. GEERTSMA, PhD; IRENE MERSOL, MS

Arch Gen Psychiatry. 1963;9(1):89-95.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Previous work reported from our laboratory^1-3 has indicated that there were various physiological influences on indole compound excretion, notably, diurnal variability, urine volume, and diet. In addition, a "stress-responsive indole substance" (SRIS) has been seen after extraction and chromatography; this substance appeared in the urine at the same time as the peak of 17-hydroxycorticosteroid excretion following corticotropin activation of the adrenal gland. The present report concerns a systematic attempt to verify the 17-hydroxycorticosteroid-SRIS relationship and, in addition, to study the effect of controlled diet, tryptophan load, and tryptophan load and corticotropin combination on indole excretion. It appears that the SRIS is of particular interest in that we have recently demonstrated increases and decreases of plasma 17-hydroxycorticosteroid levels in man from stimulation in the amygdala and hippocampus,⁴ respectively. These findings, taken in combination with the recent reports of the temporal lobe . . . [Full Text PDF of this Article]

Author Affiliations
LOS ANGELES

Biochemical Correlates Laboratory, The Neuropsychiatric Institute, University of California Medical Center.

Footnotes
Submitted for publication Nov 1, 1962.

Supported by the California Department of Mental Hygiene grant No. 61-2-22.

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