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W. J. FESSEL, MRCP; MOTOE HIRATA-HIBI, MD

Arch Gen Psychiatry. 1963;9(6):601-613.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The purposes of the present paper are: (1) to confirm the finding of abnormal circulating leukocytes in schizophrenic patients; (2) to show their finer cytological details; and (3) to discuss the effect of the finding of these abnormal cells upon our concepts of the etiology of mental disease.

The search for a cellular abnormality in the blood or tissues of psychiatric patients is almost as old as the microscope itself. Already in 1844 Andral¹ had described low red blood cell counts in some neurotic patients and stated that "... even in the neuroses the study of the state of the blood may be important." Fifty years ago, in 1914, Itten⁴⁶ reported an increase in lymphocyte count in schizophrenia and reviewed a considerable literature concerning the white cells in schizophrenia. He noted improvement when the lymphocyte count fell.

Recent reports have described morphological abnormalities . . . [Full Text PDF of this Article]

Author Affiliations
Lond, Edin; SAN FRANCISCO

Departments of Psychiatry and Medicine, University of California School of Medicine, and The Langley Porter Neuropsychiatric Institute.

Footnotes
Submitted for publication June 4, 1963.

Supported in part by USPHS grant MH04581-02 and in part by a grant (61-1-29) from the California Department of Mental Hygiene.

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